Two new lipopeptaibols, tolypocaibols A (1) and B (2), and the mixed NRPS-polyketide-shikimate natural product maximiscin [(P/M)-3)] were isolated from a Tolypocladium sp. fungal endophyte of the marine alga Spongomorpha arcta. Analysis of NMR and mass spectrometry data revealed the amino acid sequences of the lipopeptaibols, which both comprise 11 residues with a valinol C-terminus and a decanoyl acyl chain at the N-terminus. The configuration of the amino acids was determined by Marfey’s analysis. Tolypocaibols A (1) and B (2) showed moderate, selective inhibition against Gram-positive and acid-fast bacterial strains, while maximiscin [(P/M)-3)] showed moderate, broad-spectrum antibiotic activity.

中文翻译：

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Tolypocaibols：来自 Tolypocladium sp 的抗菌 Lipopeptaibols。海洋巨藻 Spongomorpha arcta 的内生菌

从Tolypocladium sp . 中分离出两种新的脂肽肽，tolypocaibols A ( 1 ) 和 B ( 2 ) 以及混合的 NRPS-聚酮化合物-莽草酸酯天然产物 maximiscin [( P / M )- 3 )] 。海藻Spongomorpha arcta的真菌内生菌。NMR 和质谱数据分析揭示了脂肽醇的氨基酸序列，它们均包含 11 个残基，C 端有缬氨醇，N 端有癸酰基链。氨基酸的构型由 Marfey 的分析确定。Tolypocabols A ( 1 ) 和 B ( 2)) 对革兰氏阳性和抗酸细菌菌株表现出中等、选择性的抑制作用，而 maximiscin [( P / M )- 3 )] 显示出中等、广谱的抗生素活性。